Introduction. Motivation is what keeps us alive. Brain structures of mesocorticolim- bic pathways help us to let us feel „rewarded“ and thus keep us motivated. But still, not everything that makes us feel rewarded keeps us alive (see alcohol, cigarettes, sweets et cetera). rTMS over left DLPFC has shown therapeutic potential in addic- tion and other neuropsychiatric diseases. In this study we investigated the effects of rTMS over left DLPFC on reward process- ing using the monetary incentive delay-task, MID-task (Knutson, 2001) in brains (fMRI) that feel especially rewarded by cigarettes. Blood oxygen level dependent (BOLD) contrasts were calculated for anticipating gains and losses and having gained or lost money. Methods. 80 smokers (final analyses 67 subjects) matching the ICD-10 criteria for smoking dependency underwent rTMS sham (as a placebo) and verum stimulation (10min, 10Hz, 90% of MT) over left DLPFC. One run of the MID-task was per- formed before and one after stimulation. Results. After verum rTMS over left DLPFC participants showed increased activity in prefrontal and somatosensory regions during gain anticipation. Contrarily, thalamic and striatal areas showed increased activity during loss anticipation. Reaction times where overall significantly lower for possible gain trials. Conclusion. rTMS over left DLPFC seems to influence smokers‘ brain activity during anticipation of potential win and loss. Interestingly activity changes in basal struc- tures could be revealed in loss but not win anticipation.
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|aktuell||22:14, 16. Jul. 2014||(6,67 MB)||Psychologie||Introduction. Motivation is what keeps us alive. Brain structures of mesocorticolim- bic pathways help us to let us feel „rewarded“ and thus keep us motivated. But still, not everything that makes us feel rewarded keeps us alive (see alcohol, cigarett|
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